Soft .beta.-adrenergic blocking agents

Details Soft .beta.-adrenergic blocking agents Soft .beta.-adrenergic blocking agents

Filed on

1986-10-23

Date issued

1989-05-09

Examiner

Gray, Bruce D.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Ester doai

Other Related Categories

514538, 514541, 560 42, A61K 3124, C01C10144

Type

Patent

Status

active

Patent number

048290866

Description

ABSTRACT:
New soft .beta.-adrenergic blocking agents, useful in the treatment or prevention of cardiovascular disorders and in the treatment of glaucoma, have the formula ##STR1## wherein n is an integer from 0 to 10; R is C.sub.6 -C.sub.12 cycloalkyl-C.sub.p H.sub.2p --, C.sub.6 -C.sub.18 polycycloalkyl-C.sub.p H.sub.2p --, C.sub.6 -C.sub.18 polycycloalkenyl-C.sub.p H.sub.2p -- or C.sub.6 C.sub.12 cycloalkenyl-C.sub.p H.sub.2p -- (wherein p is 0, 1, 2 or 3), or together with the adjacent ##STR2## group represents a variety of other complex ester groupings; R.sub.1 is C.sub.1 -C.sub.7 alkyl; and Ar is a divalent radical containing at least one aromatic nucleus. The corresponding pharmaceutically acceptable acid addition salts are also described.

REFERENCES:
Bodor, et al. Pharmaceutical Research, 1984, (3) pp. 120-125, (May, 1984).

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