Prostaglandin intermediate

Details Prostaglandin intermediate Prostaglandin intermediate

1974-06-19

1976-05-25

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602472R, 260268R, 26029365, 2603262, 2603433R, 2603462R, 2604109R, 260413, 2604488R, 260468D, 260468K, 2605011, 26050115, 26050117, 260514D, 424305, 424317, 424318, C07C 6138, C07C 6974

Patent

active

039592634

ABSTRACT:
Prostaglandin derivatives of the formula ##SPC1##
In which R.sup.4, R.sup.5, R.sup.6 and R.sup.7 each are hydrogen or lower alkyl, X is hydroxy and Y is hydrogen or X and Y together are oxo, Z is CH.sub.2 CH.sub.2 or trans CH=CH, m is an integer from one to three and n is an integer from two to five, with the proviso that at least one of R.sup.4, R.sup.5 or R.sup.6 is hydrogen, are disclosed together with a process for their preparation. The compounds in which Z is CH.sub.2 CH.sub.2 and the process are new. The new derivatives possess hypotensive, antihypertensive, bronchospasmolytic, gastric acid secretion inhibiting, abortifacient, estrus synchronizing and ovulation regulating properties. These compounds also inhibit the aggregation of platelets and promote the disaggregation of aggregated platelets. Methods for their use are also disclosed.

REFERENCES:
patent: 3849474 (1974-11-01), Abraham et a.

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