Process for the recovery of cephalosporin C and derivatives ther

Details Process for the recovery of cephalosporin C and derivatives ther Process for the recovery of cephalosporin C and derivatives ther

1975-02-11

1979-09-18

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 19, C07D50108, C07D50112

Patent

active

041683757

ABSTRACT:
A process for the recovery of cephalosporin C from an aqueous medium, including the steps of treating the medium with a sulphonyl chloride of formula R--SO.sub.2 Cl, in which R is a substituted or unsubstituted alkyl group having from 4 to 10 carbon atoms, or a substituted or unsubstituted aryl group, to convert the cephalosporin C to the corresponding sulphonamide and extracting the sulphonamide with an essentially water immiscible solvent. The sulphonyl chloride may be toluene-p-sulphonyl chloride, p-isopropylbenzenesulphonyl chloride or .beta.-naphthalenesulphonyl chloride. The molar ratio of sulphonyl chloride to cephalosporin C present in the aqueous medium is from 3 to 10. The temperature of the reaction of sulphonyl chloride with cephalosporin C is maintained in the range from 10.degree. to 20.degree. C. The water immiscible solvent is selected from ethyl acetate, n-butanol and methylisobutylketone. The pH of the reaction medium is maintained at a value of from 7.5 to 9.5 by means of a buffering agent. The extraction of the sulphonamide of cephalosporin C is carried out at a pH of from 1 to 4.

REFERENCES:
patent: 3522248 (1970-07-01), Voser
patent: 3819621 (1974-06-01), Morimoto et al.
patent: 3821208 (1974-06-01), Stables et al.
patent: 3835129 (1974-09-01), Wild
patent: 3853863 (1974-12-01), Jackson et al.

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