Polynucleotide probe and detection method for novel human clathr

Details Polynucleotide probe and detection method for novel human clathr Polynucleotide probe and detection method for novel human clathr

1998-06-17

1999-07-06

Myers, Carla J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 2431, 536 235, C12Q 168, C07H 2104

Patent

active

059196297

ABSTRACT:
The present invention provides a human clathrin-associated protein (HAP19) and polynucleotides which identify and encode HAP19. The invention also provides expression vectors and host cells and a method for producing HAP19. The invention also provides antibodies or antagonists specifically binding HAP19, and their use, in the prevention and treatment of diseases associated with expression of HAP19. The invention also provides diagnostic assays.

REFERENCES:
Maldonado-Mendoza et al (1996). Cloning and expression of a plant homologue of the small subunit of the Golgi-associated clathrin assembly protein AP19 from Camptotheca acuminata. Plant Molecular Biology 32:1149-1153, Dec. 1996.
Hillier et al (1996). EST-STS Accession No. N28456.
Kirchhausen, T., et al., "AP17 and AP19, the Mammalian Small Chains of the Clathrin-associated Protein Complexes Show Homology to Yap17p, their Putative Homolog in Yeast", Journal of Biological Chemistry, 266: 11153-11157 (1991).
Nakai, M., et al., "Cloning of the YAP19 gene encoding a putative yeast homolog of AP19, the mammalian small chain of the clathrin-assembly proteins", Biochim Biophys Acta, 1174: 282-4 (1993).
Schekman, R., et al., "Coat Proteins and Vesicle Budding", Science, 271: 1526-1533 (1996).
Seaman, M.N.J., et al., "Cytosolic and Membrane-associated Proteins Involved in the Recruitment of AP-1 Adaptors onto the Trans-Golgi Network", The Journal of Biological Chemistry, 271: 25446-25451 (1996).
Kirchhausen, T., et al., (GI 191983) GenBank Sequence Database (Accession M62418), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 2084.
Kirchhausen, T., et al., (GI 191982) GenBank Sequence Database (Accession M62418), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 2084.
Nakai, M., et al., (GI 406602) GenBank Sequence Database (Accession X70279), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 2084.
Nakai, M., et al., (GI 406601) GenBank Sequence Database (Accession X70279), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 2084.

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