Tripeptide renin inhibitors

Details Tripeptide renin inhibitors Tripeptide renin inhibitors

1987-05-04

1989-03-14

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 548569, 548342, 548215, 548950, 544400, 544159, 544168, 546247, 546335, 546336, 530331, A61K 3443, C07K 506, C07K 508, C07D24104, C07D26530, C07D21130, C07D21170, C07D26302, C07D23354, C07D20704

Patent

active

048124427

ABSTRACT:
Enzyme tripeptides of the formula: ##STR1## and analogs thereof which inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension, hyperaldosteronism or congestive heart failure or of establishing renin as a causative factor in these problems employing the novel tripeptides.

REFERENCES:
patent: 4638047 (1987-01-01), Szelke et al.

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