Pyrone derivatives as protease inhibitors and antiviral agents

Details Pyrone derivatives as protease inhibitors and antiviral agents Pyrone derivatives as protease inhibitors and antiviral agents

1994-10-12

1998-09-15

Chang, Ceila

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544149, 544224, 544238, 544333, 544374, 546148, 546152, 5462801, 5462821, 549 28, 549291, 549292, 549293, 549294, C07D30930, C07D41700, C07D40104

Patent

active

058080627

ABSTRACT:
The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.

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