Acyclic amine epoxide process

Details Acyclic amine epoxide process Acyclic amine epoxide process

1982-10-25

1984-04-10

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26039745, C07J 7100

Patent

active

044420358

ABSTRACT:
Acyclic amines are used to transform 9.alpha.-substituted-11.beta.-hydroxy 21-acyloxy steroids to the corresponding 9.beta.,11.beta.-epoxy 21-acyloxy steroids without removal of the C.sub.17 or C.sub.21 ester. The acyclic amines are cheaper and easier to prepare than previously disclosed dehydrohalogenating agents which do not produce cleavage of the C.sub.21 ester.

REFERENCES:
patent: 2838493 (1958-06-01), Graber et al.
patent: 3255185 (1966-06-01), Murrill
patent: 3499016 (1970-03-01), Lincoln et al.
patent: 3725392 (1973-04-01), Beal et al.
patent: 3980778 (1976-09-01), Ayer
patent: 4207235 (1980-06-01), Howarth et al.
H. Oediger et al., Bicyclic Amidines as Reagents in Org. Syntheses, Synthesis 591 (1972).
D. M. R. Barton et al., Synthesis and Properties of a Series of Strong But Hindered Organic Bases, J.C.S. Chem. Comm. 1136 (1981).
J. A. Hogg et al., Adrenal Hormones, etc., J. Am. Chem. Soc. 77, 4438 (1955).

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