Process for the continuous enzymatic conversion of alpha-hydroca

Details Process for the continuous enzymatic conversion of alpha-hydroca Process for the continuous enzymatic conversion of alpha-hydroca

1987-08-10

1988-11-01

Warren, Charles F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435 26, 435113, 435115, 435111, 435288, 435813, C12Q 132, C12P 1304, C12P 1312, C12P 1306

Patent

active

047820209

ABSTRACT:
.alpha.-Hydroxycarboxylic acids are continuously converted into the corresponding optically active .alpha.- aminocarboxylic acids. The conversion is carried out in a membrane reactor in the presence of nicotinamide-adenine dinucleotide increased in molecular weight by bonding to a water soluble high molecular weight material, a dehydrogenase specific for the .alpha.-hydroxycarboxylic acid, a dehydrogenase specific for the corresponding .alpha.-amino-carboxylic acid and ammonium ions. There is continuously supplied to the membrane reactor an aqueous solution of the .alpha.-hydroxycarboxylic acid to be reacted, a substantially lesser amount of the corresponding .alpha.-ketocarboxy lic acid, and an amount of ammonium ion at least equivalent to the .alpha.-hydroxycarboxylic acid to be reacted. There is maintained over the membrane a difference in pressure 1 and 15 bar. Behind the membrane, there is continuously drawn off a filtrate stream containing the .alpha.-aminocarboxylic acid formed.

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Mosbach, K. and P. O. Larsson "Immobilized Cofactors and Cofactor Fragments in General Ligand Affinity Chromatography" Enzyme Eng. III (Plenum, NY) 1975, pp. 291-298.
The Merck Index 10th Ed. (1983), Merck & Co., Inc., N.J., p. 6196, entry 6194.
Neilands, J. B., 1955, Methods in Enzyndogy, vol. I, pp. 449-454, Academic Press.

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