Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-03-14
1998-11-17
Scheiner, Toni R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
530350, C07H 2104
Patent
active
058378383
ABSTRACT:
The present invention provides substantially purified nucleic acid molecules encoding Bax inhibitor protein-1 (BI-1; SEQ ID NO: 1) or Bax inhibitor protein-2 (BI-2; SEQ ID NO: 4), nucleic acid molecules complementary thereto (SEQ ID NO: 2 and SEQ ID NO: 5, respectively), portions of such nucleic acid molecules, vectors containing the nucleic acid molecules, and host cells containing the vectors. The invention also provides methods of using such nucleic acid molecules to identify the presence of a nucleic acid molecule encoding a Bax inhibitor protein in a sample or to increase or decrease the level of expression of a Bax inhibitor protein in a cell. In addition, the invention provides substantially purified BI-1 (SEQ ID NO: 3) and BI-2 (SEQ ID NO: 6) polypeptides, portions of such polypeptides, and antibodies specific for BI-1 or BI-2. The invention also provides methods of using a BI-1 or BI-2 polypeptide, or a peptide portion thereof, to identify the presence of a member of the Bcl-2 family of proteins in a sample. The invention further provides methods of identifying agents that can modulate the binding of BI-1 or BI-2 to a Bcl-2 family protein, or that can modulate the function of BI-1 or BI-2, irrespective of its ability to bind a Bcl-2 family protein.
REFERENCES:
Walter et al., "A Novel, Conserved Gene of the Rat that is Developmentally Regulated in the Testis," Mammalian Genome 5:216-221 (1994).
Xu and Reed, "A Yeast Genetics Approach to Cloning Bax-Suppressors," Proceedings of the Am. Assoc. for Cancer Res. 38:344 (1997).
Walter, et al., Genomics, vol. 28, No. 2, pp. 301-304, 1995.
GenBank; database: EST, Accession No. N28421, publically available Jan. 4, 1996.
GenBank; Accession No. X75861, publically available Sep. 28, 1995.
Reed John C.
Xu Qunli
Scheiner Toni R.
The Burnham Institute
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