Construction and expression of synthetic genes encoding envelope

Details Construction and expression of synthetic genes encoding envelope Construction and expression of synthetic genes encoding envelope

1996-08-02

1998-11-17

Stucker, Jeffrey

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 693, 4352351, 435 5, 435 691, 4242071, 4241871, 4241841, C07K 1416, C12P 2102, C12N 700, A61K 3921

Patent

active

058378189

ABSTRACT:
A synthetic gene which codes for at least one epitope from the immunodominant conserved region of HTLV-I env. gp 21 as well as hybrid genes utilizing the synthetic gene in conjunction with other epitopes from HTLV-Ienv. gp 46 and gp 21; the corresponding gene products, recombinant vectors containing the genes, methods for producing the polypeptides and methods for detecting antibodies to HTLV-I using the polypeptides of the invention

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patent: 4939094 (1990-07-01), Kuga et al.
patent: 5003043 (1991-03-01), Akita et al.
Seiki et al. PNAS, 80:3618-3622 (1983).
Yoshida et al., PNAS, 79:2031-2035 (1982).
Parker et al., J. Immunol., 142:971-978 (1989).
Copeland et al., J. Immunol., 137:2945-2951 (Nov. 1, 1986).
Samuel et al., Science, 226:1094-1097 (Nov. 30, 1984).
Copeland et al., Biochem. and Biophys. Res. Comm., 126:672-677 (Jan. 31, 1985).

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