Imidazole-derivatives having agonistic or antagonistic activity

Details Imidazole-derivatives having agonistic or antagonistic activity Imidazole-derivatives having agonistic or antagonistic activity

1995-06-07

1998-11-17

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514398, 514400, 546278, 5483265, 5483291, 5483361, A61K 31415, C07D23360, C07D23390, C07D23394

Patent

active

058377182

ABSTRACT:
##STR1## The invention relates to imidazole-derivatives of general formula (a). The invention in particular relates to derivatives having agonistic or antagonistic activity on the histamine H.sub.3 -receptor. The novel imidazole-derivatives are isothio urea-, guanidine- and amidine-derivatives. The invention further relates to pharmaceutical compositions comprising the novel imidazole-derivatives as well as to methods for preparing the derivatives and for preparing pharmaceutical compositions having antagonistic and agonistic activity on the histamine 3 receptor.

REFERENCES:
patent: 4262125 (1981-04-01), Klaubert
patent: 5047418 (1991-09-01), Howson
H. Van Der Goot et al., "Isothiourea Analogues of Histamine as Potent Agonists or Antagonists of the Histmine H.sub.3 -Receptor," Eur. J. Med. Chem., 27, pp. 511-517 (1992).
Comprehensive Medicinal Chemistry, The Rational Design, Mechanistic Study and Therapeutic Application of Chemical Compounds, vol. 3, Pergamon Press, pp. 349-350 (1990).
Journal of Medicinal Chemistry, "Histamin H.sub.3 Ligands: Just Pharmacological Tools or Potential Therapeutic Agenst?, " Timmerman, vol. 33, No. 1, pp. 4-11, 1990.

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