Tissue-affinitive collagen for osteogenesis and method of produc

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Scleroproteins – e.g. – fibroin – elastin – silk – etc.

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530840, 514 21, 514801, 435 681, A61K 3712, C07K 300, C07K 1300

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049755277

ABSTRACT:
A good tissue-affinity and lack of antigenicity are required for the collagen used as the carrier of BMP. Conventional collagens have these properties only insufficiently. When the tyrosine content is below 2 residues/1000 residues, then the above properties of such collagens are good. Moreover, collagens excelling in the above properties can be readily obtained by using proteolytic enzymes.

REFERENCES:
patent: 4066083 (1978-01-01), Ries
patent: 4314380 (1982-02-01), Miyata et al.
patent: 4394370 (1983-07-01), Jefferies
patent: 4563350 (1986-01-01), Nathan et al.
Chemical Abstracts vol. 93, 1980 No. 21, Nov. 24 p. 431 Abstract 903:201706d Yasui et al.
Physicochemical Characterization and Molecular Organization of of the Collagen A and B Chains, R. Kent Rhodes and Edward J. Miller 1978 American Chemical Society.
Die Angewandle Makromolekulare Chemie 111 (1983) 107-122 (NR. 1701), Collagen Heterogeneity and its Functional Significance, M. Z. Abedin and R. Riemschneider.

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