Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1989-01-13
1990-12-04
Bond, Robert T.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435128, 435826, 540456, 540457, 514183, C12P 1718, C07D49818, A61K 31395
Patent
active
049753720
ABSTRACT:
Described is a new immunosuppressant, L-685,487, a monodemethylated rearranged derivative of L-683,590, produced under fermentation conditions utilizing the microorganism, unidentified Actinomycete (Merck Cultrue Collection MA 6474) ATCC No. 53828. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
REFERENCES:
patent: 4894366 (1990-01-01), Okuhara et al.
Arison Byron H.
Chen Shieh-Shung T.
Inamine Edward S.
Wicker Linda S.
Bond Robert T.
Merck & Co. , Inc.
North Robert J.
Pfeiffer Hesna J.
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