Water soluble agents effective as immunological adjuvants for st

Details Water soluble agents effective as immunological adjuvants for st Water soluble agents effective as immunological adjuvants for st

1974-10-22

1980-01-29

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Lymphokine

2601125R, 424 92, 424177, A61K 3912, C07C10352, A61K 3902, A61K 3700

Patent

active

041861949

ABSTRACT:
Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens, comprising an acyl-muramic acid group, wherein acyl means acetyl or glycolyl, and a short peptide chain linked to said acyl-muramic acid group, the first and second amino acids of said peptide chain being preferentially alanine and glutamic acid respectively.

REFERENCES:
Chem. Abst., 8th Collective Index, vol. 66-75 (1967-1971), p. 13860s.
Ghuysen, et al., Bacterial Membranes and Walls (1973), pp. 39-41.
Chaturvedi, Synthesis of Analogs of Bact. Cell Wall Glycopeptides, J. Med. Chem., vol. 9 (1966), pp. 971-973.
Kotani, et al., Sympos. Internat. on Bact. Immunostimulants, Oct. 1973, p. 8.
Lanzelotti, et al., J. Am. Chem. Soc., vol. 86, 1964, pp. 1880 & 1881.

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