Physiologically active substance designated as epimorphin genes

Details Physiologically active substance designated as epimorphin genes Physiologically active substance designated as epimorphin genes

1996-04-05

1998-11-17

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

4241391, 4241411, 4241451, 4241521, 5303871, 5303879, 53038824, A61K 39395, C07K 1600, C12P 2108

Patent

active

058372393

ABSTRACT:
Novel physiologically active substance designated as epimorphin which is capable of being expressed by a gene hybridizing with a gene probe composed of the base sequence complementary to part of the base sequence of Sequence ID No. 1 in Sequence Listing, and which is produced by mesenchymal cells derived from human or mouse, and which shows morphogenetic activity of epithelial tissue, and isoforms of the epimorphin, base sequences encoding them, modified epimorphin, in which hydrophobic region at the carboxy terminal of the epimorphin polypeptide has been deleted or replaced by non-hydrophobic polypeptide, and polyclonal antibody or monoclonal antibody produced by the use of a full length or a part of the epimorphin as an antigen are provided. The substances of the present invention can be used for elucidation of the mechanism of diseases caused by abnormal epithelium formation, diagnosis of such diseases, or development of therapeutic methods therefor.

REFERENCES:
Y. Hirai, K. Takebe, The Japanes Society of Developmental Biologists, "Development Growth & Differentiation", vol. 32, No. 4, Aug. 1990, p. 424.
John M. Chirgwin et al. "Isolation of Biologically Active Ribonucleic Acid From Sources Enriched in Ribonuclease", Biochemistry No. 18, pp. 5294-5299, American Chemical Society, 1979.
T.V. Rhynh et al., DNA Cloning, "Constructing and Screening cDNA Libraries in gt10 and gt11", IRL Press 1984, pp. 48-78.
Hirai et al., Cell, vol. 69, p. 471, 1992.
Inoue et al., Biochemical and Biophysical (Pub. Comm.) vol. 127, p. 1144, 1992.
Montesano et al., Cell, vol. 69, 697-711, 1991.
Jahoda et al., Nature, vol. 311, 560-562, 1984.

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