Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-09-27
1998-09-15
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142332, 544115, 544295, 544343, A61K 31495, A61K 31535, C07D24136, C07D40300
Patent
active
058078592
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/FR95/00358 filed Mar. 23, 1995.
The present invention relates to pharmaceutical compositions containing, as active principle, at least one compound of formula: ##STR2## or the pharmaceutically acceptable salts thereof, the novel compounds of formula (I), the salts and the preparation thereof.
According to the invention, the pharmaceutical compositions contain at least one compound of formula (I) in which hydrogen or halogen atoms or alkyl, alkoxy, amino, --N.dbd.CH--N(alk)alk', nitro, cyano, phenyl, imidazolyl, SO.sub.3 H, hydroxyl, polyfluoroalkoxy, --COOR.sub.7, --NH--CO--NR.sub.8 R.sub.9, --N(alk)--CO--NR.sub.8 R.sub.9, --N(alk-Ar)--CO--NR.sub.8 R.sub.9, --NH--CS--NR.sub.8 R.sub.9, --N(alk)--CS--NR.sub.8 R.sub.9, --NH--CO--R.sub.18, --NH--CS--R.sub.19, --NH--C(.dbd.NR.sub.20)--NR.sub.7 R.sub.9, --N(alk)--C(.dbd.NR.sub.20)--NR.sub.7 R.sub.9, --NH--SO.sub.2 --NR.sub.7 R.sub.9, --N(alk)--SO.sub.2 --NR.sub.7 R.sub.9, --CO--NR.sub.7 R.sub.9, --NH--SO.sub.2 --CF.sub.3, --NH--SO.sub.2 -alk, --NR.sub.9 R.sub.11, --S(O).sub.m -alk-Ar or --SO.sub.2 --NR.sub.7 R.sub.9 radicals, 2-oxo-1-imidazolidinyl radicals in which position -3 is optionally substituted with an alkyl radical, or 2-oxoperhydro-1-pyrimidinyl radicals in which position -3 is optionally substituted with an alkyl radical, C(COOR.sub.7)R.sub.16 or C(CONR.sub.7 R.sub.15)R.sub.16, radical in which the phenyl ring is optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy, nitro, amino, hydroxyl, cyano, -alk-NH.sub.2, --COOR.sub.7 and -alk-COOR.sub.7 radicals, --NH--COOR.sub.17, --NH--SO.sub.2 R.sub.19, --COOR.sub.7, -alk-COOR.sub.7, -alk-CONR.sub.7 R.sub.15, -alk-NR.sub.7 R.sub.15, -alk-OH, -alk-CN or -alk-Het", a phenylalkyl radical in which the phenyl ring is substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy, nitro, amino, hydroxyl, cyano, -alk-NH.sub.2, --COOR.sub.7 and -alk-COOR.sub.7 radicals, a radical --NH--CO--Ar in which Ar is optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy, nitro, amino, hydroxyl, cyano, -alk-NH.sub.2, --COOR.sub.7 and -alk-COOR.sub.7 radicals, a radical --NH--CO-Het, --NH--CO-Het", --NH--CO-alk-Het, --NH--CO-alk-Het", --NH--CO-alk-COOR.sub.7 or --NH--CO-alk-NR.sub.7 R.sub.15, a radical --NH--CO-alk-Ar in which Ar is optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy, nitro, amino, hydroxyl, cyano, -alk-NH.sub.2, --COOR.sub.7 and -alk-COOR.sub.7 radicals, a radical --NH--CO--C(Ar)(CF.sub.3)OCH.sub.3, a 1-pyrrolyl radical which is optionally substituted with a radical --COOR.sub.7, a radical --NH--CO--NH-alk-Ar in which Ar is optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy, nitro, amino, hydroxyl, cyano, -alk-NH.sub.2, --COOR.sub.7 and -alk-COOR.sub.7 radicals, a radical --NH--CO--NH-Het, --NH--CO--NH-Het", --NH--CO--NH-alk-Het or --NH--CO--NH-alk-Het", a radical --NH--CO--NH--Ar in which Ar is optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy, nitro, amino, hydroxyl, cyano, -alk-NH.sub.2, --COOR.sub.7 and -alk-COOR.sub.7 radicals, or a radical --NH--COalk, --NH--COcycloalkyl, --NH--CO--NH-alk or --NH--CO--NH.sub.2, -alk-CO--NR.sub.7 R.sub.15, a phenylalkyl radical in which the phenyl ring is substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy, nitro, amino, acetylamino, hydroxyl, cyano, -alk-NH.sub.2, --COOR.sub.7 and -alk-COOR.sub.7 radicals, a radical --R.sub.14 --COOR.sub.7, --CO--COOR.sub.7 or --NH--COOR.sub.17, a radical --NH--CO--Ar in which Ar is substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy, nitro, amino, hydroxyl, cyano, -alk-NH.sub.2, --COOR.sub.7 and -alk-COOR.sub.7 radicals, a radical --NH--CO-Het, --NH--CO-alk-Het, --NH--CO-Het", --NH--CO-alk-Het", --NH--CO-alk(2-6C)--COOR.sub.7, --NH--CO-alk(2-6C)--NH.sub.2, --NH--CO-alk-N(alk).sub.2 or --NH--CO
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Derwent Abstract of FR-A-2 696 466.
Derwent Abstract of FR-A-2 707 645.
McQuaid et al., "Synthesis and Excitatory Amino Acid Pharmacology of a Series of Heterocyclic-Fused Quinoxalinones and Quinazolinones", J. Med. Chem. 35(18):3319-3324 (1992).
Rashet et al., "A Facile Synthesis of Novel Triazoloquinoxalines and (1990).
Aloup Jean-Claude
Audiau Francois
Barreau Michel
Damour Dominique
Genevois-Borella Arielle
Coleman Brenda
Rhone-Poulenc Rorer S.A.
Shah Mukund J.
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