2-Amino-3-cyano-4-hydroxyquinolines

Details 2-Amino-3-cyano-4-hydroxyquinolines 2-Amino-3-cyano-4-hydroxyquinolines

1978-03-27

1979-11-20

Rollins, Alton D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

260465E, 2603403, 2603405R, 546 90, 546110, 544252, C07D21556, C07D22104

Patent

active

041751930

ABSTRACT:
The reaction of isatoic anhydrides with malononitrile in a reaction-inert solvent in the presence of a base to produce 2-amino-3-cyano-4-hydroxyquinolines and 2-amino-.alpha.,.alpha.-dicyanoacetophenones which are then hydrolyzed and decarboxylated under acid or base conditions to produce 2-amino-4-hydroxyquinolines, useful as intermediates for preparation of 1-oxo-1H-6-alkoxypyrimido[1,2-a]quinoline-2-carboxylic acids and esters of value as antiallergy agents.

REFERENCES:
patent: 3647802 (1972-03-01), Carney
Coppola, et al., "J. Org. Chem.," vol. 41, 1976, pp. 825-831.

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