Chemical resolution of (+)-2,3-dihydroindole-2-carboxylic acid

Details Chemical resolution of (+)-2,3-dihydroindole-2-carboxylic acid Chemical resolution of (+)-2,3-dihydroindole-2-carboxylic acid

1984-02-10

1985-05-28

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20912

Patent

active

045202052

ABSTRACT:
Described herein is a process for separating the enantiomers of (+)-2,3-dihydroindole-2-carboxylic acid, which process utilizes (+) or (-)-ephedrine as the resolving agent. The resolved acids are useful as intermediates in the preparation of angiotensin converting enzyme inhibitors.

REFERENCES:
patent: 3780062 (1973-12-01), Kaiser et al.
patent: 4374847 (1983-02-01), Gruenfeld
Derwent Abstract No. 53434E/26 of Japanese Patent Publication _J5 7081-462, published 5/21/82, (to Mochida Pharm.).
Vincent et al., Tetrahedron Letters, vol. 23, No. 16, pp. 1677-1680, _(May, 1982).

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