Resolution of (.+-.)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]

Details Resolution of (.+-.)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b] Resolution of (.+-.)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]

1983-08-16

1985-05-28

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546134, C07D49304

Patent

active

045202036

ABSTRACT:
Racemic (.+-.)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid is resolved with cinchonine to obtain directly the pure salt of the (+)-enantiomer with cinchonine and converting the latter salt to the pure (+)-enantiomer.

REFERENCES:
patent: 3939178 (1976-02-01), Demerson et al.
patent: 3988365 (1976-10-01), Gallegra
patent: 4118394 (1978-10-01), Demerson et al.
patent: 4230860 (1980-10-01), Raghu
patent: 4399284 (1983-08-01), Cannata et al.
Merck Index, 9th Edition, pp. 295, 2276.
Demerson et al., J. Med. Chem., 18, 189 (1975).

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