Cephalosporins

Details Cephalosporins Cephalosporins

1978-07-06

1985-05-28

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 23, 544 25, 544 27, 544 28, C07D50134

Patent

active

045201943

ABSTRACT:
A 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]cephalosporin derivative of the formula; ##STR1## wherein R.sub.3 is hydrogen or a residue of a nucleophilic compound; R.sub.2 NH is an amino group which may optionally be protected, pharmaceutically acceptable salt or ester thereof, is found to have excellent anti-bacterial activity against a broad spectrum of bacteria inclusive of gram-negative bacteria such as Escherichia coli, Serratia marcescens, Proteus rettgeri, Enterobacter cloacae and Citrobacter freundii. Thus, this compound may be used for an antibacterial agent in therapeutical purposes.

REFERENCES:
patent: 4098888 (1978-07-01), Ochiai et al.
Bucourt et al., "C. R. Acad. Sc. Paris", May, 1977, pp. 1847-1849.

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