Peptides useful for altering bone resorption

Details Peptides useful for altering bone resorption Peptides useful for altering bone resorption

1995-04-12

1998-09-15

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 13, 514 14, 514 15, 514 16, 514 17, 530317, 530324, 530325, 530326, 530327, 530328, 530329, A61K 3808, A61K 3810, A61K 3812, A61K 3816

Patent

active

058078193

ABSTRACT:
The present invention provides Arg--Gly--Asp peptides that can alter the binding of osteoclasts to a matrix such as bone or can selectively alter integrin receptor binding. The invention also provides methods of using the Arg--Gly--Asp peptides to alter .alpha..sub.V .beta..sub.3 integrin receptor-mediated binding of a cell such as an osteoclast, endothelial cell or smooth muscle cell to a matrix. The invention further provides methods for ameliorating the severity of a pathology characterized, in part, by an undesirable level of bone resorption, angiogenesis or restenosis in a subject.

REFERENCES:
patent: 4517686 (1985-05-01), Ruoslahti et al.
patent: 4578079 (1986-03-01), Ruoslahti et al.
patent: 4589881 (1986-05-01), Pierschbacher et al.
patent: 4614517 (1986-09-01), Ruoslahti et al.
patent: 4654314 (1987-03-01), Takagi et al.
patent: 4661111 (1987-04-01), Ruoslahti et al.
patent: 4792525 (1988-12-01), Ruoslahti et al.
patent: 5041380 (1991-08-01), Ruoslahti et al.
patent: 5192746 (1993-03-01), Lobl et al.
patent: 5227469 (1993-07-01), Lazarus et al.
Aumailley et al., "Arg-Gly-Asp Constrained within Cyclic Pentapeptides Strong and Selective Inhibitors of Cell Adhesion to Vitronectin and Laminin Fragment P1," FEBS Letters 291(1):50-54 (1991).
Choi et al., "Inhibition of Neointimal Hyperplasia by Blocking .alpha..sub.v .beta..sub.3 Integrin with a Small Peptide Antagonist GpenGRGDSPCA," J. Vascular Surg. 19(1):125-134 (1994).
Fauchere et al., "Modulation of the Activity and Assessment of the Receptor Selectivity in a Series of New RGD-containing Peptides," Int'l J. Peptide & Protein Res. 42(5):440-444 (1993).
PCT Search Report (dated 9 Nov. 1995), International application No. PCT/US95/04741.
Nesbitt, Stephen et al., "Biochemical Characterization of Human Osteoclast Integrins." J. Biol. Chem. 268:16737-16745 (1993).
Hughes, D.E. et al., "Integrin Expression in Human Bone." J. Bone & Mineral Res. 8:527-533 (1993).
Ross, R. Patrick et al., "Interactions Between the Bone Matrix Proteins Osteopontin and Bone Sialoprotein and the Osteoclast Integrin .alpha..sub.v .beta..sub.3 Potentiate Bone Resorption." J. Biol. Chem. 268:9901-9907 (1993).
Chuntharapai Anan et al., "Blocking Monoclonal Antibodies to .alpha..sub.v .beta..sub.3 Integrin: A Unique Epitope of .alpha..sub.v .beta..sub.3 Integrin is Present on Human Osteoclasts." Experimental Cell Res. 205:345-352 (1993).
Helfrich, Miep H. et al., "Rat Osteoclasts Adhere to a Wide Range of RGD (Arg-Gly-Asp) Peptide-Containing Proteins, Including the Bone Sialoproteins and Fibronectin, via a .beta..sub.3 Integrin." J. Bone and Mineral Res. 7:335-343 (1992).
Miyauchi, Akimitsu et al., "Recognition of Osteopontin and Related Peptides by an .alpha..sub.v .beta..sub.3 Integrin Stimulates Immediate Cell Signals in Osteoclasts." J. Biol. Chem. 266:20369-20374 (1991).
Yamakawa, Kensuke et al., "An Arg-Gly-Asp Peptide Stimulates Ca.sup.2+ Efflux From Osteoclast Precursors Through a Novel Mechanism." American Physiological Society. 651-657 (1994).
Horton, M.A. et al., "Arg-Gly-Asp (RGD) Peptides and the Anti-Vitronectin Receptor Antibody 23c6 Inhibit Dentine Resorption and Cell Spreading by Osteoclasts." Experimental Cell Res. 195:368-375 (1991).
Horton, Michael A. et al., "Modulation of Vitronectin Receptor-Mediated Osteoclast Adhesion by Arg-Gly-Asp Peptide Analogs: A Structure-Function Analysis." J. Bone and Mineral Res. 8:239-247 (1993).
Sato, M. et al., "Echistatin is a Potent Inhibitor of Bone Resorption in Culture." J. Cell Biol. 111:1713-1723 (1990).

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