6-aminomethyl-furo-(3,4-c)-pyridine derivatives and therapeutic

Details 6-aminomethyl-furo-(3,4-c)-pyridine derivatives and therapeutic 6-aminomethyl-furo-(3,4-c)-pyridine derivatives and therapeutic

1985-06-07

1986-07-22

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546116, A61K 31395, C07D49102

Patent

active

046020209

ABSTRACT:
This invention relates to 1,3 - dihydro-6-aminomethyl-7-hydroxy-furo-(3,4-c)- pyridine derivatives of the general formula I ##STR1## wherein A.sub.1, A.sub.2, R.sub.1 and R.sub.2 represent various substituents, to pharmaceutically acceptable salts of such compounds, to a process for the preparation of compounds comprising reacting a 6-chloromethyl-7-benzoxy derivative of the general formula II ##STR2## with an excess of an amine derivative ##STR3## in a non-polar solvent, at a temperature not exceeding 20.degree. C., which leads to the desired substitution in position 6, followed by an acidic treatment to cleave the benzyl group and, finally to an anti-allergic composition of matter comprising, as an essential ingredient therein, an effective amount of one of these compounds together with an appropriate diluent or carrier.

REFERENCES:
patent: 3763173 (1973-09-01), Barth
patent: 4448962 (1984-05-01), Irikura et al.
Morrison and Boyd Org. Chem. 3rd Ed. p. 746.

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