N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromb

Details N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromb N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromb

1979-11-19

1986-07-22

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

548341, 548336, 544139, 546210, 514326, 514240, 514397, 514399, A61K 31415, A61K 2700, A61K 31445, C07D23354

Patent

active

046020160

ABSTRACT:
N-(mono or disubstituted phenoxyalkyl)imidazoles and the pharmaceutically acceptable acid addition salts thereof are able to selectively inhibit the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacycline synthetase or cyclooxygenase enzymes and are thus useful in the treatment of ischaemic heart disease, stroke, transient ischaemic attack, thrombosis, migraine, and the vascular complications of diabetes.

REFERENCES:
patent: 3534061 (1970-10-01), Black
patent: 4078071 (1978-03-01), Walker
Moncada et al., Prostaglandins, vol. 13, pp. 611-618 (1977).
Needleman et al., Proc. Natl. Acad. Sci., USA, vol. 74, pp. 1716-1720 (1977).
Tai et al., Biochem. Biophys. Res. Commun., vol. 80, pp. 236-242 (1978).
Yoshimoto et al., Prostaglandins, vol. 16, pp. 529-540 (1978).

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