Combinatorial synthesis and high-throughput screening of a Rev-i

Details Combinatorial synthesis and high-throughput screening of a Rev-i Combinatorial synthesis and high-throughput screening of a Rev-i

1995-05-11

1998-09-15

Achutamurthy, Ponnathapura

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

436501, 436524, 435 4, G01N 33543, G01N 33551, C12Q 100

Patent

active

058077545

ABSTRACT:
An n.times.m.times.p array of different chemical compounds, each having the following scaffold structure: ##STR1## wherein n, m and p are integers, A, B and C are organic structural moieties representing diversity elements. The novel compounds present in this array are useful as inhibitors of binding of Rev protein to a Rev response element.

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Jung et al. "Multiple Peptide Synthesis Methods and Their Applications"; Angewandte Chemie. Apr. 1992, vol. 31, No. 4, pp. 367-383.
Chemical abstract, vol. 120, No. 22. May 30, 1994 (Columbus, Ohio, USA), p. 658, col. 1, abstract No. 280277. Hogan, J.C. "Aminimide-containing molecules and materials as molecular recognition agents".
Chemical abstract, vol. 123, No. 23. Dec. 4, 1995 (Columbus, Ohio, USA), p. 909, column 2, the abstract No. 314023k. Hogan, J.C., "Systematic modular production of aminimide-and oxazolone-based molecules having selected properties".

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