Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-03-25
1999-12-14
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514326, 514397, 544372, 544386, 544387, 544388, 544391, 544395, 546207, 546210, 5483147, A01N 4360, C07D40300, C07D40302, C07D40100
Patent
active
060018356
ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
REFERENCES:
patent: 5015653 (1991-05-01), Olson
patent: 5055467 (1991-10-01), Albaugh
patent: 5073671 (1991-12-01), Weber et al.
patent: 5159083 (1992-10-01), Thurkauf et al.
patent: 5371101 (1994-12-01), Itoh et al.
patent: 5384319 (1995-01-01), Ferrini
patent: 5576313 (1996-11-01), Fisher et al.
Smith et al, Chemical Abstract vol. 120 No. 217238, "Conversion of amides & lactams to thioamides & thiolactams" (1994).
Cabini et al, Chemical Abstract vol. 87 No. 23726, "Apparent molal heat cap. in aq. sol. of mol. containing peptide linkage." (1977).
Neville et al, Chemical Abstract vol. 126 No. 8133 "Prep. of piperazine & homopiperazine inhibitors of farnesyl-protein transferase" (1991).
Exp. Opin. Ther. Patents, vol. 5(12), pp. 1269-1285 (1995), by S. L. Graham.
Exp. Opin. Ther. Patents, vol. 6(12) (1996), pp. 12951304, by S. L. Graham, et al.
J. of Biol. Chem., vol. 269, No. 44, pp. 27706-27714 (1994), by G. L. James, et al.
J. of Biol. Chem., vol. 270, No. 11, pp. 6221-6226 (1995), by G. L. James, et al.
Science, vol. 260, pp. 1934-1937 (1993), by N. E. Kohl, et al.
Proc. Natl. Acad. Sci. USA, vol. 91, pp. 9141-9145 (1994), by N. E. Kohl, et al.
Nature Medicine, vol. 1, No. 8, pp. 792-797 (1995), by N. E. Kohl, et al.
Cancer Research, vol. 55, pp. 5302-5309 (1995), by L. Sepp-Lorenzino, et al .
Dinsmore Christopher J.
Williams Theresa M.
Covington Raymond
Daniel Mark R.
Kight John
Merck & Co. , Inc.
Muthard David A.
LandOfFree
Inhibitors of farnesyl-protein transferase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors of farnesyl-protein transferase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of farnesyl-protein transferase will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-863637