Process for the preparation of 1,3-disubstituted-2-azetidinones

Details Process for the preparation of 1,3-disubstituted-2-azetidinones Process for the preparation of 1,3-disubstituted-2-azetidinones

1979-02-21

1981-04-28

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

544193, 544215, 549 59, 2602454, 424244, C07D20508, C07D20102, C07D40304, A67K 31395

Patent

active

042644984

ABSTRACT:
A process for preparing an azetidinone of the formula: ##STR1## which comprises reacting a C-unsubstituted methyleneamine of the formula: ##STR2## with R.sup.2 --CH.sub.2 COOH, its acid halide or anhydride, in the presence of boron trihalide and an organic base, wherein R.sup.1 is an organic residue bearing a carboxy group or its derivative and R.sup.2 is azido, substituted amino, halogen, acyloxy, alkoxy, aryloxy or aralkoxy.

REFERENCES:
patent: 3943123 (1976-03-01), Bose
Ziegler et al., Monat. 99, 2128-2133, (1968).
Mukeyee et al., Synthesis 1973, 334-337.
Smolin et al., "S-triazines and Derivatives", (1959), pp. 493, 494.
Kamiya et al., Chem. Abs. 85, 21078b, (1976).

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