Stable aqueous solutions of glucans and glucan derivatives capab

Details Stable aqueous solutions of glucans and glucan derivatives capab Stable aqueous solutions of glucans and glucan derivatives capab

1976-02-02

1980-06-10

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

424176, A61K 3170, A61K 3100

Patent

active

042073120

ABSTRACT:
The glucans and glucan derivatives which inhibit the growth of sarcoma 180 in mice are only sparingly soluble in water, and their aqueous solutions are unstable. In the presence of 0.1 to 1.0 g/dl water soluble dextran, hydroxyethyl starch, carboxymethyl cellulose, or polyethylene glycol, they form relatively concentrated and stable solutions, particularly in the presence of hexoses, pentoses or sugar alcohols having 5 or 6 carbon atoms.

REFERENCES:
patent: 3987166 (1976-10-01), Komatsu et al.
American Hospital Formulary Service, 1966, p. 10.00, Testolactone.
Husa, Pharmaceutical Dispensing, 6th Ed., 1966, Mack Publishing Co. pp. 212, 213, 293 & 400.
Chemical Abstracts 74: 91107g (1971).
Chemical Abstracts 74: 110212f (1971).
Chemical Abstracts 79: 142893y (1973).
The Merck Index, 8th Ed., 1968, Merck & Co., Inc., Rahway, N.J., pp. 210 & 956.

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