Pharmaceutical method for the treatment of severe blood loss and

Details Pharmaceutical method for the treatment of severe blood loss and Pharmaceutical method for the treatment of severe blood loss and

1996-05-03

1999-01-05

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514212, 514921, A61K 31175, A61K 3155

Patent

active

058563601

ABSTRACT:
This invention is directed to a pharmacologically acceptable composition for inhibiting or treating hemorrhagic shock in a mammal. The composition includes a K.sub.ATP inhibitor and a pharmacologically acceptable carrier, with the K.sub.ATP inhibitor being present in an amount sufficient to inhibit or treat hemorrhagic shock in the mammal. The invention is also directed to a method for inhibiting or treating hemorrhagic shock in a mammal. The method includes administering to the mammal an amount of a K.sub.ATP channel inhibitor sufficient to inhibit or treat hemorrhagic shock in the mammal. In a preferred form of the invention, the K.sub.ATP channel inhibitor is selected from the group consisting of a sulfonylurea, a guanidine, a phenothiazine, an imidazoline, TMB-8 (also known as (8-N, N-diethylamino) octyl-3,4,5-trimethoxybenzoate), 2,3-butanedione monoxime, disopyramide, gliquidone, chlorpromazine, AMP-NPP (also known as 5'-adenylylamidodiphosphate), flecainide, MS-551 (also known as propylamino!ethylamino)-2,4(1H,3H)-pyrimidinedione HCl) and combinations thereof.

REFERENCES:
DiPiro et al., "Pharmacotherapy, A Pathophysiologic Approach" Elsevier Science, New York, NY (1989) pp. 1542-1543.
Sewster et al., "Facts and Comparisons", J. B. Lipincott Co., St. Louis, Mo., (Jun. 1985), p. 52.
"The ATP-Sensitive K.sup.+ Channel Mediates Hypotension in Endotoxemia and Hypoxic Lactic Acidosis in Dog", by: Donald W. Landry and Juan A. Oliver, (J. Clin. Invest., vol. 89, Jun., 1992), pp. 2071-2074.
T. Norske Laegeforen, vol. 95, No. 32, 1975, Norway, pp. 1825-1830, Dedichen, H., "Blodningssjokk".
Lakartidningen, vol. 78, No. 38, 1981, Sweden, pp. 3275-3278, Haljamae et al., "Cellulara Aspekter Pa Patofysiologi Och Terapi Vid Hypovolemisk Chock".
Science, vol. 270, No. 5239, 17 Nov. 1995, pp. 1166-1170, Inagaki, N. et al., "Reconstitution of /Katp: An Inward Rectifier Subunit Plus The Sulfonylurea Receptor".
ENDOCRINOLOGY, vol. 88, No. 1, Jan. 1971, pp. 138-143, Cerchio et al., "Serum Insulin and Growth Hormone Response to Hemorrhagic Shock".
Eur J Pharmacol, May 30, 1991, 198 (1) P101-4, Netherlands, Muller, M. et al.: "Chlorpromazine and related phenothiazines inhibit the ATP--sensitive K+channel".

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