Erythropoietin isoforms

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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530395, 530397, 530412, 530416, 435 694, 2041829, A61K 3818, C07K 14505, C07K 118, C07K 128

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active

058562982

ABSTRACT:
Erythropoietin isoforms having a specific number of sialic acids per erythropoietin molecule are disclosed. Also disclosed are mixtures of such isoforms, pharmaceutical compositions containing such isoforms or mixtures thereof and methods of obtaining the erythropoietin isoforms.

REFERENCES:
patent: 4377513 (1983-03-01), Sugimoto et al.
patent: 4667016 (1987-05-01), Lai et al.
patent: 4703008 (1987-10-01), Lin
patent: 4801540 (1989-01-01), Hiatt et al.
patent: 4888282 (1989-12-01), Beremand et al.
patent: 5002870 (1991-03-01), Leavitt et al.
patent: 5451662 (1995-09-01), Naveh et al.
Fuhr et al., Biochemical and Biophysical Research Communications 98: 930-935, Feb. 27,1981.
Viau et al., Biochemical and Biophysical Research Communications 117: 324-331, Nov. 30, 1983.
Havel et al., Proc. Natl. Acad. Sci. 77: 4349-4353, Jul. 1980.
Welch et al., Journal of Biological Chemistry 259: 4501-4513, Apr. 1984.
Napier et al "Isoelectric Focussing of Human Urinary Erythropoietiu" IRCS Med. SCI4:437 (1976).
Andreux et al "Etude de l'erythropoietiue. . . " Annales Pharma. Francaises 31(1):29-36, (1973).
Fuhr et al., Biochem. & Biophys. Res. Comm.98: 930-935, Feb. 27, 1981.
Viau et al., Biochem. & Biophys. Res. Comm. 117: 324-331, Nov/ 30, 1983.
Havel et al., PNAS 77: 4349-4353, Jul. 1980.
Krystal et al., Blood 67: 71-79, Jan. 1986.
Welch et al., J. Biol. Chem. 259: 4501-4513, Apr. 1984.
Dordal et al., Endocrinology 116: 2293-2299, 1985.
Sasaki et al., J. Biol. Chem. 262:12059-12076, Sep. 5, 1987.
Copsey et al., Genetically Eng. Human Therap. Drugs, pp. 25-26, 257, 1988.
Dube et al., J. Biol. Chem. 263:17516-17521, 25 Nov. 1988.
Goldwasser, "Erythropoietiu & red cell differentiation", in Control of Cellular Division and Devel: Part A, pp. 487-494, 1981.
Lukowsky et al, "Studies on the role of Sialic Acid in The hysical and Biological Properties of Erythropoietin", Can. J. Biochem. 50:909-917, 1972.
Ashwell et al. Methods Enzymol. 50 , 287-288 (1978).
Bradford Anal. Biochem. 72 , 248-254 (1976).
Burnette et al. Anal. Biochem. 112 , 195-203 (1981).
Cotes et al. Nature 191 , 1065-1067 (Sep. 1961).
Davis et al. Biochemistry 26 , 2633-2638 (1987).
Egrie et al. Immunobiology 172l ,213-224 (1986).
Elliott et al. Blood 74 ,Supp. 1, A 1228 (1989).
Elliott et al. Gene 79 , 167-180 (1989).
Fukuda et al. Blood 73 , 84-89 (Jan. 1989).
Goldwasser et al. J. Biol. Chem. 249 , 4202-4206 (Jul. 1974).
Holmes et al. Anal. Biochem. 117 , 193 (1981).
Iscove et al. J.Cell Physiol. 83 , 309-320 (1974).
Kunkel et al. Methods Enzymol. 154 , 367-382 (1987).
Lai et al. J. Biol. Chem. 261 , 3116-3121 (Mar. 1986).
Law et al. Proc. Natl. Acad. Sci. USA 83 , 6920-6924 (Sep. 1986).
Lee et al. J. Biol. Chem. 264 , 13848-13855 (Aug. 1989).
Lin et al. Proc. Natl. Acad. Sci. USA 82 , 7580-7584 (Nov. 1985).
Messing Methods Enzymol. 101 , 20-78 (1983).
Miyake et al. J. Biol. Chem., 252 , 5558-5564 (Aug. 1977).
Morrell et al. J. Biol Chem 243, 155-59 (Jan. 1968).
Mutsaers et al. Eur. J. Biochem. 156 , 651-654 (1986).
Phelps et al. Biochem. Biophys. Acta. 791 , 226-238 (1984).
Shelton et al Biochem. Med. 12 , 45-54 (1975).
Takeuchi et al. J. Biol. Chem. 263 , 3657-3663 (Mar. 1988).
Takeuchi et al. J. Chromatogr. 400 , 207-213 (1987).
Yanisch-Perron et al. Gene 33 , 103-119 (1985).
Dorado et al. Biochem. Medicine 6 , 238-245 (1972).
Napier IRCS Med. Sci. Biochem. 4 , 437 (1976).

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