Mitochondrial adenylate kinase

Details Mitochondrial adenylate kinase Mitochondrial adenylate kinase

1999-01-04

1999-12-14

Achutamurthy, Ponnathapura

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

424 945, C12N 912, A61K 3851

Patent

active

060016248

ABSTRACT:
The present invention provides a human mitochondrial adenylate kinase (HMAK) and polynucleotides which encode HMAK. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HMAK.

REFERENCES:
Zelezniker, R.J. et al., "Evidence for Compartmentalized Adenylate Kinase Catalysis Serving a High Energy Phosphoryl Transfer Function in Rat Skeletal Muscle", J. Biol. Chem., 270(13), 7311-7319 (1995).
Xu, G. et al., "Characterization of Human Adenylate Kinase 3 (AK3) cDNA and Mapping of the AK3 Pseudogene to an Intron of the NF1 Gene", Genomics, 13: 537-542 (1992).
Yamada, M. et al., "Cloning and Characterization of cDNA for Mitochondrial GTP:ATP Phosphotransferase of Bovine Liver", J. Biol. Chem., 264: 19192-19199 (1989).
Shahjahan, M. (Direct Submission), GenBank Sequence Database (Accession 217576), Sep. 22, 1992 National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 217576).
Shahjahan, M., (Direct Submission), GenBank Sequence Database (Accession D10373 D90434) Sep. 22, 1992, National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 217571; GI 217572; GI 217573; GI 2176574).
Xu, G., (Direct Submission), GenBank Sequence Database (Accession 28577), Jan. 18, 1995, National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 28577).
Xu, G., (Direct Submission), GenBank Sequence Database (Accession X60673 S41502), Jan. 18, 1995 National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 28576).
Hillier, L., (Direct Submission), GenBank Sequence Database (Accession AA007279), Jul. 25, 1996 National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1463313).
Hillier, L., (Direct Submission), GenBank Sequence Database (Accession H65871), Oct. 18, 1995 National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1024611).
Hillier, L., (Direct Submission), GenBank Sequence Database (Accession R70844), Jun. 01, 1995 National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 844361).
Hillier, L., (Direct Submission), GenBank Sequence Database (Accession R39487), May 4, 1995 National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 796943).
Hillier, L., et al., "Homo sapiens cDNA clone 429214 5' similar to SW:KAD3Bovin P08760 GTP:AMP Phosphotransferase mitochondrial," EMEST EMBL Database entry HSA07279, Accession No. AA007279; Jul. 28, 1996, XP002070698.
Auffray, C., et al., "Homo sapiens cDNA sequence," EMEST EMBL Database entry HSBA7D052, Accession No. F01168, Mar. 07, 1995, XP002070699.
The Institute for Genomic Research: Est 12881 Uterus tumor I Homo sapiens cDNA 5' end similar to adenylate kinase isozyme 3, mitochondrial, EMEST EMBL Database entry HSZZ05381, Accession No. AA300170, Apr. 18, 1997, XP002070700.
Yamada, M., et al., "Cloning and characterization of cDNA for mitochondrial GTP:AMP phosphotransferase of bovine liver," Journal of Biological Chemistry, 264:19192-19199 (1989).
Tanabe, T., et al., "Tissue-specific and developmentally regulated expression of the genes encoding adenylate kinase isozymes," Journal of Biochemistry, 113:200-207 (1993), XP002070697.

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