Structural gene of pneumococcal protein

Details Structural gene of pneumococcal protein Structural gene of pneumococcal protein

1995-06-06

1999-01-05

Houtteman, Scott W.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

535 237, C12M 120

Patent

active

058561706

ABSTRACT:
A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membrane anchor region of the whole protein. The protein is formed by insertion-duplication of mutagenesis of S. pneumoniae with pspA gene and expression of the truncated protein into the growth medium.

REFERENCES:
patent: 4496538 (1985-01-01), Gordon
patent: 4673574 (1987-06-01), Anderson
Briles, D., Genetic Analysis of Pneumococcal Surface Protein A using Southern Blot Hybrid . . . General Meeting Abstract, American Society for Microbiology, Dec., 1992.
Briles, D. and Yother, J., Sequence Analysis of pspA Reveals that Pneumoccal Surface Protein A is a Complex Protein Containing at least Four Distinct Domains, Abstract, 3rd International ASM Conference on Streptococcal Genetics, Jun., 1990.
Briles, D. and Yother, J., Generation of truncated forms of pneumococcal surface protein A (PspA) and DNA sequencing of pspA, Abstract, 90th Annual Meeting of the American Society for Microbiology, May, 1990.
McDaniel et al. (IV) Infect Immun. 59:222-228, 1991.
Talkington DF, DL Crimmins, DC Voellinger, J Yother, DE Briles: A 43 KDa Pneumococcal surface protein A (PspA): Isolation, Protective Abilities, and Structural Analysis of the Amino Terminal Sequence. Infect. and Immun. 59: 1285-1289, 1991.
Yother, J., Briles, D.E. Structural and evoluntionary relationships in PspA, a surface protein of Streptococcus pneumoniae, as revealed by sequence analysis. J. Bacteriol. 174:601-609, 1992.
Yother, J. Handsome, G.L., Briles, D.E. Truncated forms of PspA that are secreted from Streptococcus pneumoniae and their use in functional studies and cloning of the pspA gene. J. Bacteriol. 174:610-618, 1992.
Watson, J.D., Tooze, J., Kurtz, D.T., Recombinant DNA, Scientific American Books, Chap. 7, pp. 96-97, 1983.
Freifelder, David, Molecular Biology, (Second Edition) Jones and Bartlett Publishers, Inc. pp. 448-450, 1986.
Berry, A. Yother, J., Briles, D.E., Hansman, D., and Paton, J.C. Infection and Immunity, Jul., 1989, pp. 2027-2042.
McDaniel, L.S., Yother, J., Vijayakumar, M., McGarry, L., Guild, W.R. and Briles, D.E., J. Exp. Med. vol. 165, Feb. 1987, pp. 381-394.
Dertzbaugh, M.T. and Macrina, F.L. Gene 82, pp. 335-342, 1989.
Briles, D.E., Crain, M.J., Gray, B.M., Forman, C., and Yother, J, Infection and Immunity, Jan., 1992, pp. 111-116.
Crain, M.J., Waltman, W.D. II, Turner, J.S. Yother, J., Talkington, D.F., McDaniel, L.S., Gary, B.M., and Briles, D.E., Infection and Immunity, Oct., 1990, pp. 3293-3299.
McDaniel, L.S., Sheffield, J.S., Delucchi, P., and Briles, D.E., Infection and Immunity, Jan. 1991, pp. 222-228.
Talkington, D.F., Crimmins, D.L., Voellinger, D.C., Yother, J., and Briles, D.E., Infection and Immunity, Apr. 1991, pp. 1285-1289.
McDaniel, L.S., Scott, G., Widenhofer, K., Carroll, J.M., and Briles, D.E., Microbial Pathogenesis 1986, 1:519-531.
McDaniel, L.S., Sheffield, J.S., Swiatlo, E., Yother, J., Crain, M.J., Briles, D.E., Microbial Pathogenesis 1992, 13:1-9.
McDaniel, L.S., Scott, G., Kearney, J.F. and Briles, D.E., J. Exp. Med. vol. 160, Aug. 1984, pp. 386-397.
Stover, C.K. et al., Nature, vol. 351, 6 Jun. 1991, pp. 456-460.
DNA Sequencing, Chapter 13; A Laboratory Manual, 1989.
Bowie, J.U., Reidhaar-Olson, J.F., Lim, W.A. and Sauer, R.T., Science, vol. 247, pp. 1306-1310.
Kumar, V., Urban, J.L., Horvath, S.J. and Hood, L., Proc. Natl. Acad. Sci. USA 87 (1990), pp. 1337-1341.
Yother et al., Strep. Genetics, p. 11, Jun. 1990.
McDaniel et al., 1989 Abstracts of the 89th Annual Meeting of the ASM, Abstract D-255.
Rijn et al., Infection and Immunity, Feb., 1980, pp. 444-448; and.
McDaniel et al. (I) J. Exp. Med. 160:386-397, 1984.

Affiliated with

Also associated with

Rating

Structural gene of pneumococcal protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Structural gene of pneumococcal protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Structural gene of pneumococcal protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-861504