Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-11-07
1999-01-05
Degen, Nancy
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
530350, G01N 3353, C07K 100
Patent
active
058561099
ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode a human homolog of rat elastase IV (HEIV) expressed in pancreas tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode HEIV, hybridization probes or oligonucleotides for the detection of HEIV-encoding nucleotide sequences, and a diagnostic test based on HEIV-encoding nucleic acid molecules. The present invention further provides for genetically engineered host cells for the expression of HEIV, biologically active HEIV, antibodies capable for binding specifically to HEIV, and treatment methods comprising administration of compounds, such antibodies or inhibitors, capable of binding HEIV to alter its activity.
REFERENCES:
Edwards, P.D. et al., "Synthetic Inhibitors of Elastase", Med. Res. Rev., Mar. 1994, 142(2), pp. 127-194--Abstract Only.
Gross, V. et al., "Inflammatory Mediators and Cytokins--New Aspects of the Pathophysiology and Assessment of Severity of Acute Pancreatitis?", Hepatogastroenterology, Dec. 1993, 40(6), pp. 522-530--Abstract Only.
Kang, J. et al., "Identification of cDNSs Encoding Two Novel Rat Pancreatic Serine Proteases", Gene, 110 (2), 181-187 (1992) Abstract Only (EMBL accession X59014).
Ngo, J.T. et al., "Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox", The Protein Folding Problem and Tertiary Structure Prediction, 1994, pp. 433-440.
Gewirtz, A.M. et al., "Facilitating oligonucleotide delivery: Helping antisense deliver on its promise", Proc. Natl. Acad. Sci. USA, Apr. 1996, 93, pp. 3161-3163.
James, W., "Towards gene-inhibition therapy: a review of progress and prospects in the field of antiviral antisense nucleic acids and ribozymes", Antiviral Chemistry & Chemotherapy, 1991, 2(4), pp. 191-214.
Braxton Scott M.
Delegeane Angelo M.
Diep Dinh
Billings Lucy J.
Degen Nancy
Incyte Pharmaceuticals Inc.
Wang Andrew
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