Homologously recombinant slow growing mycobacteria and uses ther

Details Homologously recombinant slow growing mycobacteria and uses ther Homologously recombinant slow growing mycobacteria and uses ther

1993-07-22

1998-09-15

Ketter, James

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4352523, 4352531, C12N 1563, C12N 121

Patent

active

058077235

ABSTRACT:
A method of transforming slow-growing mycobacteria, such as M. bovis BCG, M. leprae, M. tuberculosis M. avium, M. intracellulare and M. africanum; a method of manipulating genomic DNA of slow-growing mycobacteria through homologous recombination; a method of producing homologously recombinant (HR) slow-growing mycobacteria in which heterologous DNA is integrated into the genomic DNA at a homologous locus; homologously recombinant (HR) slow-growing mycobacteria having heterologous DNA integrated into their genomic DNA at a homologous locus; and mycobacterial DNA useful as a genetic marker.

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