Catalytic antibodies for carbamate activation by a non-spontaneo

Details Catalytic antibodies for carbamate activation by a non-spontaneo Catalytic antibodies for carbamate activation by a non-spontaneo

1996-05-24

1998-09-15

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

4351885, 424 941, 4241751, C12N 900, C12Q 125

Patent

active

058076883

ABSTRACT:
Catalytic antibodies capable of catalysing activation of a carbamate (--O--CO--NH--) containing prodrug suitable for Antibody Directed Abzyme Prodrug Therapy (ADAPT) by catalysing breakdown of the prodrug at the carbamate position by a non-spontaneous reaction mechanism. The non-spontaneous reaction preferably has a B.sub.Ac 2 mechanism and the prodrug is a preferably a nitrogen mustard aryl carbamate. The invention also includes relevant immunogens, screens for catalytic activity using short transition state analogues and ADAPT systems.

REFERENCES:
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