Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1

Details Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1 Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1

1985-07-29

1987-01-27

Evans, J. E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07F 938, A61K 31045, A61K 3166

Patent

active

046393382

ABSTRACT:
The invention relates to a novel crystal modification, containing water of crystallization, of disodium 3-amino-1-hydroxypropane-1,1-diphosphonate of the formula ##STR1## and to a process for the manufacture thereof. This modification is suitable for the oral treatment of disorders of the calcium and phosphate metabolism and associated diseases in warm-blooded animals.

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patent: 4327039 (1982-04-01), Blum et al.
patent: 4407761 (1983-10-01), Blum et al.
patent: 4446052 (1984-05-01), Sunberg et al.
Chem. Abstr. 78, 94528z.

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