Tetrazoles and their use as hypoglycemic agents

Details Tetrazoles and their use as hypoglycemic agents Tetrazoles and their use as hypoglycemic agents

1988-02-12

1989-07-04

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546276, 548253, C07D25702, C07D21362, C07D40306, C07D41112

Patent

active

048452319

ABSTRACT:
Compounds of the formula: ##STR1## in which R is a substituted or unsubstituted monocyclic or bicyclic alkyl group containing from 3 to 8 ring carbon atoms, wherein any substituent is alkyl of 1 to 3 carbon atoms, oxo, hydroxy, carboxy or when the hydroxy and carboxy substituents taken together they form a 1,3-carbonyloxy lactone ring closed structure;

REFERENCES:
patent: 3435115 (1969-03-01), Holland
patent: 3894033 (1975-07-01), Holland
Sohda et al.--Studies on Antidiabetic Agents. II. Synthesis of 5-[4-(1-methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione; 4/22/82.
Derwent Abstract 41767--Solidiuretic tetrazolyl-benzene:sulphonamide derivs.-prepd. e.g. by reaction of 4-thienyl-or furfuryl amino-2H-methyl--anilino-5-cyano benzene: sulfonamide with hydrazoic acid, 11/6/80.
Derwent Abstract 35639C/20 of J. 55047620--Pharmaceutical compsn. for treating gastric ulcers--contains opt. hydroxylated phenyl-alkylene, alkenylene, oxyalkylene or carboxy:alkylene carboxylic acid or tetrazole derivs.; 9/29/78.
Derwent Abstract 271464/44 of E.P. 123543--New alkanoic acid derivs.--useful as leukotriene antagonists for treating allergic and cardiovascular diseases; 4/21/83.

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