Nitrogen- and sulfur-containing lipid compounds their production

Details Nitrogen- and sulfur-containing lipid compounds their production Nitrogen- and sulfur-containing lipid compounds their production

1987-07-23

1989-07-04

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

546331, 546334, 546339, 546340, 546248, 548193, 548194, 548146, 548574, 560155, 560170, 568672, 568678, 544158, 544398, C07D29508, C07D29510, C07C14910

Patent

active

048452190

ABSTRACT:
A compound of the general formula [I]: ##STR1## wherein R.sub.1 represents a higher alkyl group or an N-(higher alkyl)carbamoyl group, R.sub.2 represents a lower alkyl group, an acyl group having at least three carbon atoms, an N-(lower alkyl)carbamoyl group, an N-(lower alkyl)thiocarbamoyl group or a benzyl group, R represents a primary, secondary or tertiary amino group or a quaternary ammonium group, x is 1 or 2, y is a number of 0, 1 or 2, and z is an integer of 2-10, or a pharmaceutically acceptable salt thereof. The novel substances have both anti-tumor activity and platelet activating factor-inhibiting property, and they are effective as an anti-tumor agent without circulatory trouble.

REFERENCES:
patent: 4426525 (1984-01-01), Hozumi
Hackh's Chemical Dictionary, 4th ed., McGraw-Hill 1972, p. 16.

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