Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl es

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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C07C22934

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active

053939158

ABSTRACT:
A method for the solid-liquid separation of a suspension of .alpha.-L-aspartyl-L-phenylalanine methyl ester (.alpha.-APM) or its hydrochloride salt (.alpha.-APM.HCl), wherein an aqueous suspension of .alpha.-L-aspartyl-L-phenylalanine methyl ester or its hydrochloride salt is subjected to continuous separation by vacuum filtration.

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"Chemical Engineers' Handbook", Robert H. Perry Cecil H. Chilton, 5th Edition; 19-80; 1973.
Horizontal Belt Filters In Wet-Process Phosphoric Acid Plants; R. J. B. McNally et al. 1978 Proc. Annu. Meet-Fert. Ind. Round Table.
Utilization of Horizontal Belt Filters for Washing Fine Alumina Seed and Kiln Feed Product Richard Crawford: Donald A. Dahlstrom Light Met. 1984.
Chemical Abstracts, 159814h, vol. 115, No. 15, Oct. 14, 1991, & JP-A-3 106 899, May 7, 1991, p. 1008, T. Harada, et al., "Crystallization of Alpha-L-Aspartyl-L-Phenylalanine Methyl Ester".
Chemical Abstracts, 56620t, vol. 108, No. 7, Nov. 15, 1988, & JP-A-62 153 298, Jul. 8, 1987, p. 780, Y. Miyaki, et al., "A Method for the Purification of Aspartame by Dialysis".
M. P. Deutscher, "Guide to Protein Purification", 1990, pp. 67-68.

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