Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-06-27
1999-08-03
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
4241331, A61K 3802, A61K 39395
Patent
active
059325429
ABSTRACT:
This invention relates to the novel identification of myelin-associated glycoprotein ("MAG") as a potent inhibitor of neural regeneration. More particularly, this invention relates to compositions and methods useful for reversing inhibition of neural regeneration in the central and peripheral nervous system. Assays to monitor the effects of MAG on neural regeneration and to identify agents which will block or promote the inhibitory effects of MAG on neural outgrowth are provided. Screening methods for identifying such agents are also provided. This invention also relates to compositions and methods using agents that can reverse the inhibitory effects of MAG on neural regeneration. Methods for regulating and for promoting neural growth or regeneration in the nervous system, methods for treating injuries or damage to nervous tissue or neurons, and methods for treating neural degeneration associated with disorders or diseases, comprising the step of administering at least one of the compositions according to this invention are provided.
REFERENCES:
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Aulakh Charanjit S.
Haley, Jr. James F.
Research Foundation of CUNY, Hunter College
Rotman Alan L.
Ruskin Barbara A.
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