Solid phase peptide synthesizer

Details Solid phase peptide synthesizer Solid phase peptide synthesizer

1993-08-27

1995-01-10

Czaja, Donald E.

Chemical apparatus and process disinfecting, deodorizing, preser

Chemical reactor

Organic polymerization

422 62, 422 81, 436 55, 935 87, 935 88, 530333, 530334, B01J 1000

Patent

active

053804953

ABSTRACT:
Solid-phase peptide synthesis is performed with solvent/reagent delivery and measuring systems open to atmospheric pressure coupled to pressurized transfer and reaction systems. The delivery and measuring systems consists of multiple solvent vessels connected to a metering vessel through individual, uninterrupted solvent lines. The metering vessel is connected to a transfer vessel by a valve through which solvent is gravity fed to the transfer vessel. The solvent is now in a closed, single pathway system and can be pressurized from the transfer vessel to a reaction vessel. This closed system allows the complete inversion of the reaction vessel; with the advantage of guaranteeing complete resin to solvent contact without any possibility of loss of resin product. All of the steps are accomplished by the opening and closing of individual valves that are controlled through a personal computer and system software that allow the user to do these steps individually or in any combination and length.

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