Modulation of drug resistance via ubiquitin carboxy-terminal hyd

Details Modulation of drug resistance via ubiquitin carboxy-terminal hyd Modulation of drug resistance via ubiquitin carboxy-terminal hyd

1997-11-14

1999-08-03

Degen, Nancy

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 698, 4351723, 4352542, 4353201, 536 232, C12Q 168, C12N 1563, C12N 119, C07H 2104

Patent

active

059324228

ABSTRACT:
The expression of ubiquitin carboxy-terminal hydrolase is aberrent in cells that are resistant to treatment with chemical agents. Accordingly, the invention features methods for diagnosing and treating drug resistant cells (e.g., tumor cells) by examining and modulating the expression or activity of UCH.

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