Immonogenic oligosaccharide compositions

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4241941, 42419611, 42419711, 4242341, 530403, 530416, 530417, A61K 39385

Patent

active

058075534

ABSTRACT:
The invention provides immunogenic oligosaccharide compositions and methods of making and using them. In particular, the compositions comprise oligosaccharides covalently coupled to carrier protein, wherein the resultant conjugate has been shown to contain specific immunogenic epitopes and elicits a protectively immunogenic response.

REFERENCES:
patent: 4619828 (1986-10-01), Gordon
patent: 4644059 (1987-02-01), Gordon
patent: 4663160 (1987-05-01), Tsay
patent: 4673574 (1987-06-01), Anderson
patent: 4695624 (1987-09-01), Marburg et al.
patent: 4711779 (1987-12-01), Porro et al.
patent: 4771127 (1988-09-01), Cryz et al.
patent: 4882317 (1989-11-01), Marburg et al.
patent: 5153312 (1992-10-01), Porro
Anderson, P., Infect. Immun., 39:233-238, 1983.
Anderson, P., Pichichero, M.E., and Insel, R.A., J. Clin. Invest., 76:52-59, 1985a.
Anderson, P., Pichichero, M.E., and Insel, R.A., J. Pediatr., 107:346-351, 1985b.
Anderson, P.W., Pichichero, M.E., Insel, R.A., Betts, R., Eby, R., and Smith, D.J., J. Immunol., 137:1181-1186, 1986.
Anderson, P.W., Pichichero, M.E., Stein, E.C., Porcelli, S., Betts, R.F., Connuch, D.M., Korones, D., Insel, R.A., Zabradnick, J.M., and Eby, R., J. Immunol., 142:2464-2468, 1989.
Avery, O.T. and Goebel, W.F., J. Exp. Med., 50:566-550, 1929.
Barra, A., Dogan, R., Prued'homme, J.L., Bajart, A., Danue, B. and Fritzell, B., Vaccine, 11:1003-1006, 1993.
Bixler, G.S. and Pillai, S., "The Cellular Basis of the Immune Response to Conjugate Vaccines" Conjugate Vaccines. Contributions to Microbiology and Immunology, J.M. Cruse and R.E. Lewis, Eds., 10:18-47 1989.
Bolan, G., Broome, C.V., Fracklam, R.R., Pitkaytis, B.D., Fraser, D.W., and Schlech, W.F., III, Ann, Internal Med., 104(1):1-6, 1986.
Borgano, J.M., McLean, A.A., Vella, P.P., Canepa, I., Davidson, W.L., and Hilleman, M.R., Proc. Soc. Exp. Biol. Med., 157:148-154, 1978.
Broome, C.V., Facklam, R.R., and Fraser, D.W., N. Engl. J. Med., 303:549-552, 1980.
Bruyn, G.A.W., and van Furth, R., Eur. J. Clin. Microbiol. Infect. Dis., 10:897-910, 1991.
Chudwin, D.S., Artrip, S.C., Korenbilt, A., Schiffman, G., and Rao, S., Infect. Immun., 50:213-217, 1985.
Connelly, K.K., and Starke, J.R., Sem. Resp. Inf., 6:204-216, 1991.
Eby, R., Koster, M., Hogerman, D. and Malinoski, F., "Pneumococcal Conjugate Vaccines", in Modern Approaches to New Vaccines Including Prevention of AIDS, E. Norrby, F. Brown, R. Chanock and H. Ginsberg, eds., Cold Spring Harbor Laboratory Press, New York, 1994.
Fattom, A., Lue, C., Szu, S.C., Mestecky, J., Schiffman, G., Brylar, D., Vann., W.F., Watson, D., Kimzey, L.M., Robbins, J.B. and Schneerson, R., Infect. and Immun., 58(7):2309-2312, 1990.
Fattom, A., Vann, W.F., Szu, S.C., Schneerson, R., Robbins, J.B., Chu, C., Sutton, A., Vickers, J.C., London, W.T., Curfman, B., Hardagree, M.C., and Shiloach, Infect. and Immun., 56(9):2292-2298, 1988.
Forrester, H.L., Jahnigen, D.W., and LaForce, F.M., Am. J. Med., 83:425-430, 1987.
Gaur, A., Arunan, K., Singh, O. and Talwar, G.P., Int. Immunol., 2(2):151-155, 1990.
Giebink, G.S., Koskela, M., Vella, P.P., Harris, M. and Chap, T.L., J. Inf. Dis., 167:347-355, 1993.
Goebel, W.F. and Avery, O.T., J. Exp. Med., 50:521-531, 1929.
Hazelwood, M., Nusrat, R., Kumararatne, D.S., Goodal, M., Raykundalia, C., Wang, D.G., Joyce, H.J., Milford-Wards, A., Forte, M. and Pahor, A., Clin. Ex. Immunol., 93:157-164, 1993.
Hakamori, S. and Kannagi, R., Carbohydrate Antigens in Higher Animals, in Handbook of Experimental Immunology, vol. 1, D.M. Weir, L. A. Herzenberg, C. Blackwell and L.A. Herzenberg, eds., Blackwell, Oxford, 1986 (Ch. 9):9.1-9.39.
Heidelberger, M. and Avery, O.T., J. Exp. Med., 38:73-79, 1929.
Hilleman, M.R., Carlson, A.J., Jr., McLean, A.A., Vella, P.O., Weibel, R.E., and Woodhour, A.F., Rev. Infect. Dis., 3(suppl):S31-S42, 1981.
Jones, J.K.N. and Perry, M.B., J. Am. Chem. Soc., 79:2787-2793, 1957.
Kenne, L. and Lindberg, B., "Bacterial Polysaccharides" in The Polysaccharides, vol. 2, G.O. Aspinall, Ed., Academic Press, New York, 1983, p. 287-362.
Lee, C-J., Banks, S.D. and Li, J.P., Crit. Rev. Microbio., 18(2):89-114, 1991.
Lees, A., Finkelman, F., Inman, J.K., Witherspoon, K., Johnson, P., Kennedy, J. and Mond, J.J., Vaccine, 12:1160-1166, 1994.
Lock, R.A., Hansman, D., and Paton, J.C., Microbial Pathogen., 12:137-143, 1992.
Madore, D.V., Jackson, C.L., Phipps, D.C., Penridge Pediatric Association, Popejoy, L.A., Eby, R., and Smith, D.H., Pediatric., 85(3):331-337, 1990.
Malcolm, A.J., Messner, P., Sleytr, U.B., Smith, R.H., and Unger, F.M., Crystalline Bacterial Cell Surface Layers (S-layers) as Combined Carrier/Adjuvants for Conjugate Vaccines, in Immobilized Macromolecules: Application Potentials, U.B. Sleytr, P. Messner, D. Pum and M. Sara, Eds., pp. 195-207, Springer-Verlag, London, 1993a.
Malcolm, A.J., Best, M.W., Szarka, R.J., Mosleh, Z., Unger, F., M., Messner, P. and Sleytr, U.B., Surface Layers of Bacillus alvei as a Carrier for a Streptococcus pneumoniae Conjugate Vaccine in "Advances in Bacterial Paracrystalline Surface Layers," Ch. 21, pp. 219-233, T.J. Beveridge and S.F. Koval, Ed., Plenum Press, New York, 1993b.
Lindberg, et al., "Structural Studies of the Capsular Polysaccharide from Streptococcus pneumoniae Type I", Carb. Res., 78:111-117 (1980).
Marburg, S., Jorn, D., Tolman, R.L., Arison, B., McCauley, J., Kniskern, P.J., Hagopian, A., and Vella, P.O., J. Am. Chem. Soc., 108:5282-5287, 1986.
Mufson, M.A., Hughey, D., and Lydick, E., J. Infect. Dis., 151:749-750, 1985.
Mufson, M.A., Krause, H.E., Schiffman, G., and Hughey, D.E., Am. J. Med. Sci., 293:279-284, 1987.
Nielsen, S.V., and Henrichsen, J., Scand. J. Infect. Dis., 25:165-170, 1993.
Paton, J.C., Lock, R.A., Lees, C-J., Li, J.P., Berry, A.M., Mitchell, T.J., Andrew, P.W., Hansman, D., and Boulnois, G.J., Infection and Immunity, 59(7):2297-2304, 1991.
Peeters, C.C.A.M., Tenbergen-Meekes, A-M., Poolman, J.T., Berutett, M., Zegers, B.J.M. and Rijkers, G.T., Infection and Immunity, 59(10):3504-3510, 1991.
Perlmutter, R.M., Hansburg, D., Briles, D.E., Nicolotti, R.A., and Davie, J.M., J. Immunol., 121(2):566-572, 1978.
Sanders, L.A.M., Rijkers, G.T., Kuis, W., Tenbergen-Meekes, A.J., de Graff-Meeker, B.R., Hiemstra, I. and Zegers, B.J.M., J. Allergy Clin. Immunol., 91:110-119, 1993.
Shildt, R.A., Boyd, J.F., McCracken, J.D., Schiffman, G., and Giolma, J.P., Med. Pediatr. Oncol., 11:305, 1983.
Schneerson, R., Barrera, O., Sutton, A., and Robins, J.B., J. Exp. Med., 152:361-376, 1980.
Schneerson, R., Robbins, J.B., Chu, C., Sutton, A., Vann, W., Vickers, J.C., London, W.T., Curfman, B., and Hardegree, M.C., Infection and Immunity, 45(3):582-591, 1984.
Schneerson, R., Robbins, J.B., Parke, J.C., Bell, C., Schlesselman, J.J. Sutton, A., Wang, Z., Schiffman, G., Karpas, A., and Shiloach, J., Infection and Immunity, 52(2):519-528, 1986.
Schneerson, R., Levi, L., Robbins, J.B., Bryla, D.M., Schiffman, G., and Lagergard, T., Infection and Immunity, 60(9):3528-3532, 1992.
Seid, R.C., Jr., Boykins, R.A., Liu, D.F., Kibrough, K.W., Hsieh, C.L., Eby, R., Glycoconj. J., 6:489-498, 1989.
Sell, S.H., Wright, P.F., Vaugh, W.K., Thompson, J., and Schiffman, G., Rev. Infect. Dis., 3(suppl):S97-S107, 1981.
Shapiro, E.D., and Clemens, J.D., Ann. Intern. Med., 101:325-330, 1984.
Shapiro, E.D., N. Engl. J. Med., 316:1272-1273, 1987.
Shapiro, E.D., "Pneumococcal Vaccine", in Vaccines and Immunotherapy, S.J. Fryz Jr., ed., Pergamon Press, New York, 1991, Ch. 10: pp. 127-139.
Siber, G.R., Weitzman, S.A., Aisenberg, A.C., Weinstein, H.J., and Schiffman, G., N. Engl. J. Med., 299(9):442-448, 1978.
Simberkoff, M.S., Cross, A.P., Al-Ibrahim, M., Baltch, A.L., Geiseler, P.J., Nadler, J., Richmond, A.S., Smith, R.P., Schiffman, G., and Shepard, D.S., N. Engl. J. Med., 315(21):1318-1327, 1986.
Simberkoff, M.S., "Pnuemococcal Vaccine in Adults", in Immunization, Ch. 10:125-135, M.A. Sande, and R.K. Root, ed., Churchill Livingstone, New York,, 1989.
Sims, R.V., Steinman, W.C., McConville, J.H., King, L.K., Zwick, W.C., and Schwartz, J.C., 1988, Ann. Intern. Med., 108(5):653-657, 1988.
Slack, J., Der-Balian, G.P., N

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Immonogenic oligosaccharide compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Immonogenic oligosaccharide compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immonogenic oligosaccharide compositions will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-84801

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.