Method of activating prothrombin

Details Method of activating prothrombin Method of activating prothrombin

1993-03-19

1995-02-28

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435174, 424 9464, C12N 1100, C12N 1116, C12N 900, A61K 37547

Patent

active

053936663

ABSTRACT:
There is disclosed a method of activating prothrombin by means of trypsin, wherein the prothrombin is recovered from a blood or plasma fraction, treated with trypsin immobilized on a water-insoluble carrier, and separated from the immobilized trypsin after activation.

REFERENCES:
patent: 4334018 (1982-06-01), Kirchhof
patent: 4610962 (1986-09-01), Takagi et al.
Bajaj, S. P. et al. "The Journal of Biological Chemistry," vol. 248 (22), Nov. 25, 1973, pp. 7729-7741.
Heldebrant, C. M., et al., "The Journal of Biological Chemistry," vol. 248 (10), May 25, 1973, pp. 3642-3652.
Van de Graaff, et al., Concepts of Human Anatomy and Physiology, pp. 712-713, 1986 WCB Publishers.
Rimon, A., et al., "Biochemistry," vol. 5 (2), Dubuque, Iowa Feb. 1966, pp. 792-798.
Radcliffe, R. D., et al., "The Journal of Biological Chemistry," vol. 248 (19), Oct. 10, 1973, pp. 6788-6795.
Fujikawa, K. et al., "Biochemistry," vol. 13 (26), 1974, pp. 5290-5299.
Papahadjopoulos, P., et al., "Biochemistry," vol. 3 (12), Dec. 1964, pp. 1931-1939.
Pechet, L., et al., "Federation Proc.," vol. 19, Mar. 1960, p. 64, #2-abstract.
Kisiel, W., et al., "Biochim. et Biophys. Acta." vol. 329, 1973, pp. 221-232.
Aldrich, F. L. et al., "Federation Proc." vol. 17, Mar. 1958, p. 179, #704-abstract.
Alexander, B., et al., "Proc. of the VIIIth Congress of European Soc. of Hematol.," vol. 2, 1962 #404.
Eagle, H. et al., "The J. of Gen. Physiology," vol. 20, 1937, pp. 543-560.
Derwent Abstract (SU-A-994,556).
Derwent Abstract (DD-A-137 325).
Zubairov et al., Voprosy Meditsinskoi Khimii (1976) pp. 187-191 (English translation).
American Journal of Physiology (1961), 201(2), pp. 298-302.
Fandaburu et al., "Prothrombin Activation With Trypsin As Enzyme," Am. J. Physical, vol. 201:298-302, (1961).
Zubairov et al., "Vosprosy Meditsinskoi Khimii 0043.260000," pp. 187-191, (1976) abs.
Miletich et al., "The Synthesis Of Sulfated Dextran Beads For Isolation Of Human Plasma Coagulation Factors II, IX, and X.sup.1," Analytical Biochemistry, vol. 105:304-310, (1980).
Kisiel et al., "The Action Of Factor Xa. Thrombin And Trypsin On Human Factor II," Biochimica et biophysica Acta, vol. 329:221-232, (1973).
Brummelhuis, "Preparation Of The Prothrombin Complex," Methods of Plasma Protein Fractionation, ed. M. Curling, Acad. Press, pp. 117-128, (1980).

Affiliated with

Also associated with

Rating

Method of activating prothrombin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of activating prothrombin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of activating prothrombin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-847911