FDG synthesizer using columns

Details FDG synthesizer using columns FDG synthesizer using columns

1997-03-26

1999-08-03

Bhat, Nina

Chemical apparatus and process disinfecting, deodorizing, preser

Chemical reactor

For radioactive reactant or product

422DIG903, 376168, G21C 100, G21G 106

Patent

active

059321784

ABSTRACT:
An FDG synthesizer, which comprises: a labeling reaction resin column comprising a column filled with a polymer-supported phase-transfer target water, and performing a labeling reaction between the thus trapped reaction vessel for receiving a reaction intermediate product obtained from the labeling reaction, and performing a hydrolysis reaction by adding a strong acidic aqueous solution or a strong alkaline aqueous solution thereto, on the other hand. The above-mentioned hydrolysis reaction vessel may be replaced with a cation-exchange resin column having a heating device and a flow rate control device of the reaction intermediate product.

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patent: 5759513 (1998-06-01), Nakazawa
patent: 5808020 (1998-09-01), Ferrieri et al.
G. Keith Mulholland, "Simple Rapid Hydrolysis of Acetyl Protecting Groups in the FDG Synthesis Using Cation Exchange Resins", Nucl. Med. Biol., 22, 19-23, (1995). F!fluoro-D-glucose by Direct Nucleophilic Exchange on a Quaternary 4-aminopyridinium Resin", Nucl. Med. Biol. vol. 17, No. 3, 1990, pp. 273-279.
Hamacher et al, "Efficient Stereospecific Synthesis of No-Carrier-Added Nucleophilic Substitution", The Journal of Nuclear Medicine, vol. 27, No. 2, Feb. 1986, pp. 235-238.
M. Diksic and D. Jolly, "New High-Yield Synthesis of .sup.18 F-Labelled 2-deoxy-2-fluoro-D-glucose", Int. J. Appl. Radiat. Isot, vol. 34, No. 6, 1983, pp. 893-896. Compounds and Radiopharmaceuticals, vol. XXV, No. 7, 1988, pp. 721-729.

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