Triterpene saponins having anti-inflammatory, mucolytic and anti

Details Triterpene saponins having anti-inflammatory, mucolytic and anti Triterpene saponins having anti-inflammatory, mucolytic and anti

1987-06-26

1989-11-07

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536 5, 536 63, 536128, 4241951, 514 26, 514 33, 514 34, A61K 31705, A61K 3170, A61K 3578

Patent

active

048793760

ABSTRACT:
Triterpene saponins of formula ##STR1## wherein R.sub.1 is H or OH and R.sub.2 is a tetrasaccharide, or alternatly pentasaccharide, chain have antiinflammatory, mucolytic and antiedemic activities. Said saponins are isolated from roots and bark of Crossopteryx febrifuga, for instance by precipitating them, in form of a complex with cholesterol or sytosterol, from an alcoholic extract of the vegetal material and by partitioning the precipitate between an apolar solvent, which subtracts the complexing agent and a polar solvent in which saponins are soluble.

REFERENCES:
patent: 3886272 (1975-05-01), Parkhurst et al.
patent: 4147777 (1979-04-01), Mustich
patent: 4524067 (1985-06-01), Arichi et al.
Chirva et al.; Chemical Abstracts 81:120925z (1974).
Krokhmalyuk et al.; Chemical Abstracts 84:74569y (1976).
Higuchi et al.; Phytochemistry 26(1): 229-235 (1987).
Erdelmeier et al.; J. Chromatog. 389(1): 345-349 (1987).

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