Stabilized microspheres and methods of preparation

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

436532, 436528, 427 8, 424420, 424450, C12Q 100, A61K 3706

Patent

active

053935276

ABSTRACT:
Stabilized microspherical particles having hydrophobic liquid cores prepared as oil-in-water microemulsions. The particles are stabilized by a surface layer comprising an amphiphilic compound and may be functionalized to allow covalent coupling of a ligand to the surface of the particle. When used as tracers in assays, a water insoluble dye may be incorporated in the core liquid of the microparticles.

REFERENCES:
patent: 4370160 (1983-01-01), Ziemelis
patent: 4480041 (1984-10-01), Myles et al.
patent: 4927538 (1990-05-01), Senshu et al.
patent: 5100591 (1992-03-01), Leclef et al.
S. Amselem, et al., "Polymeric Biodegradable Lipospheres as Vaccine Delivery Systems", Polymers for Advanced Technologies, 3:351-357 (1992).
W. Yu, et al., "A novel approach to the preparation of injectable emulsion by a spontaneous emulsification process", Int. J. Pharm. 89, 139-146 (1993).
C.-Y. Guo, et al., "Functionalized, Probe-containing, Latex Nanospheres", Anal. Biochem. 207, 241-148, (1992).
Iwamoto et al., 1991, J. Pharmaceutical Sciences, 80, 219.
Batzri and Korn, 1973, Biochim. Biophys. Acta 298, 1015.
Liposomes--A Practical Approach, IRL Press, R. R. C. New, ed., p. 63.
Perrette, et al., 1991, J. Pharm. Pharmacol., 43, 154.
Hamann, et al., 1989, 5th International Conf. Pharm. Tech. 1, 99.
Hamann, et al., 1987, Acta Pharm. Techno. 33, 67.
Regen et al., Biochem. Biophys. Res. Comm., vol. 101, No. 1, pp. 131-136, issued Jul. 16, 1981.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Stabilized microspheres and methods of preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stabilized microspheres and methods of preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stabilized microspheres and methods of preparation will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-847036

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.