Isolation and structural elucidation of the cytostatic linear de

Details Isolation and structural elucidation of the cytostatic linear de Isolation and structural elucidation of the cytostatic linear de

Filed on

1989-05-16

Date issued

1989-11-07

Examiner

Lee, Lester L.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Designated organic active ingredient containing

SubSubClass

Peptide containing doai

Other Related Categories

514 16, 514 21, 530329, 530330, A61K 3702, C07K 706

Type

Patent

Status

active

Patent number

048792780

Description

ABSTRACT:
A new cytostatic depsipeptide, designated "dolastatin 15", was isolated from the Indian Ocean shell-like mollusk Dolabella auricularia. Dolastatin 15 inhibited growth of the PS leukemia with ED.sub.50 0.0024 .mu.g/mL. Pharmaceutical preparations and therapeutic regimens utilizing Dolastatin 15, its synthetic counterpart and pharmaceutically active derivatives are disclosed. Dolastatin 15 has the structural formula: ##STR1##

REFERENCES:
patent: 4414205 (1983-11-01), Pettit
patent: 4486414 (1984-12-01), Pettit
patent: 4816444 (1989-03-01), Pettit et al.

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