Pyridyl and pyridazinyl substituted thyronine compounds having s

Details Pyridyl and pyridazinyl substituted thyronine compounds having s Pyridyl and pyridazinyl substituted thyronine compounds having s

1986-01-14

1988-08-23

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544239, 546290, 568716, C07D40310, A61K 3150

Patent

active

047661216

ABSTRACT:
This invention relates to chemical compounds which have selective thyromimetic activity. A compound of this invention is 3,5-dibromo-3'-[6-oxo-3(1H)-pyridazinylmethyl]-thyronine.

REFERENCES:
patent: 3477954 (1969-11-01), Reynolds et al.
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Gharib, H. et al., "Radioimmunoassay for Triiodothyronine (T.sub.3): I. Affinity and Specificity of the Antibody for T.sub.3," J. Clin. Endocrinol. Metab., vol. 33, No. 3, pp. 509-516, (Sep. 1971).
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Korener, D. et al., "Binding of Selected Iodothyronine Analogues to Receptor Sites of Isolated Rat Hepatic Nuclei," J. Biol. Chem., vol. 250, No. 16, pp. 6417-6423, (1975).
Goldfine, I. D. et al., "Activities of Thyroid Hormones and Related Compounds in an in Vitro Thymocyte Assay", J. Biol. Chem., vol. 251, No. 14, pp. 4233-4238, (1976).
Simon, Z. et al., "Studiu Structura Chimica--Activitate Biologica Pentru Situsul Fixator de Tiroxina al Prealbuminei Umane," Timisoara Med., vol. 26, No. 3, pp. 26-28, (1981).
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