Tyr-Arg-vasopressin antagonists

Details Tyr-Arg-vasopressin antagonists Tyr-Arg-vasopressin antagonists

1986-12-04

1988-08-23

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514807, 530315, A61K 3734, C07K 716

Patent

active

047661089

ABSTRACT:
Vasopressin antagonists which have a dipeptide tail composed of a neutral and basic amino acid unit demonstrate potent V.sub.1 and V.sub.2 -antagonist activity. Two species of this invention, which are prepared by solid phase peptide synthesis, are [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylene propionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-7-tyrosine-8-arginine-9-desglycine]- vasopressin and [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-7-arginine-8-tyrosine-9-desglycine]- vasopressin.

REFERENCES:
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M. Manning et al., Nature, 308, 652 (1984).
M. Manning et al., (9th American Peptide Symposium) pp. 599-602.

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