Preparation of 3'azido-3-'-deoxythymidine

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 11, 536116, 536122, C07H 1700, C07H 1504

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049219502

ABSTRACT:
This invention relates to a new synthetic process for the manufacture of zidovudine from the starting material D-xylose involving:

REFERENCES:
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C. D. Anderson, et al., J. of Amer. Chem. Soc., vol. LXXX, 1958, pp. 5247-5252, Synthesis and Ammonolysis of Methyl 2,3-Anhydro-D-Ribofuranoside.
J. of the Amer. Chem. Soc., vol. 108, No. 11, 1986, pp. 3115-3117.
J. Carbohydrates, Nucleosides, Nucleotides, 2(2), 147-151, (1975).
Synthesis of Some Nucleotides Derived from 3'-Deoxythymidine, vol. 8, No. 12, Dec., 1969.
J. Med. Chem. 1980, 23, 1088-1094, Nucleosides, 116.
J. Med. Chem. 1984, 27, 986-990, Pyrazolo[4,3-d]pyrimidine Nucleosides, Synthesis and Antiviral Activity of 1-B-D-Ribofuranosyl -3-methyl-6-substituted-7H-pyrazolo[4,3-d]pyrimidin-7-ones, Pier Giovanni Baraldi et al.
Anderson et al., J.A.C.S., vol. 80 (1958), pp. 5247-5252.
Horwitz et al., J. Org. Chem. 29, pp. 2076-2078 (1964).
Glinski et al., J. Org. Chem. 38 (1973), pp. 4299-4305.
Lin et al., J. Med. Chem. 1978, vol. 21, No. 1, pp. 109-112.
Yarchoan et al., The Lancet, 1986, pp. 575-580.

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